The Endocannabinoid System and How THC Kills Cancer

By Marco Torres Guest writer for Wake Up World

Endocannabinoid-System-and-How-THC-Cures-Cancer

There are over 20,000 studies on cannabinoids in the pubmed database, and few scientists who concentrate their work around cannabinoids can deny the tremendous therapeutic potential of cannabis. In fact, Dr. Christina Sanchez, a molecular biologist at Compultense University in Madrid Spain, has completed extensive research which led to one of the first discoveries that THC does indeed kill cancer cells.

Read original post at the Source: The Endocannabinoid System and How THC Kills Cancer

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CBD Blocks Psychoactivity of THC = Huge Win for Patients Needing High Dosages THC

By Dragana Komnenov PhD

RxLeaf

CBD binds to a different site on the CB1 that, when filled, prevents THC from binding. This is very big news for cancer and chronic pain patients who need high doses of THC to manage their symptoms.

Cannabis is a complex mixture of hundreds of different cannabinoids, terpenes and other chemicals that may modulate the effects of THC, the main psychoactive constituent of the plant. A number of studies now support the view that CBD may reduce the negative psychotropic effects of THC while also enhancing its positive therapeutic actions.

Continue reading “CBD Blocks Psychoactivity of THC = Huge Win for Patients Needing High Dosages THC”

Catch-22 is Alive & Well ~ How I Learned To Live With Chronic Pain Without Opioids

In the Spring, my wife, Paula Cas wrote a post about my battle with chronic pain, pain clinics, and opioid use. Catch-22 Is Alive And Well.

Just wanted to post a short update about how things have been going since then.

After a lot of research, trial and error, I have come up with non-Opioid, no prescription treatment for my chronic pain that works for all but my worst pain days … Rainy days or extreme cold.

A high THC strain of Medical Cannabis usually with the colors purple or blue in the name in flower or dab form. I also found a website with high quality hemp based CBD Oil products, 750mg twice a day most days and 1500mg twice a day on bad days, that has been great help for pain and sleep. The final product in my new pain management program is from a company where my wife is involved. Plexus Worldwide offers a product called Nerve and Plexus Ease which has done wonders for my neuropathy.**

I have once again put the back surgeon on hold while I continue t0 do all I can to keep surgery, braces, canes and wheelchairs at bay as long as possible.**

**I am not a health care professional. This article is based on my own experience and is no way meant to be construed as anything other than a sharing of those experiences. As in all matters do your own due diligence and consult your personal physicians.

Catch 22 Is Alive And Well

Paths I Walk

By Paula & Oro Cas

Catch-22:  A dilemma or difficult circumstance from which there is no escape because of mutually conflicting or dependent conditions.

I sit looking at this document wondering how to write about the craptastic Catch-22 that has appeared in my husband’s life. My husband is one of the millions of people who suffer with chronic pain. His journey to where he is today began 35 years ago when he worked for a traveling carnival. While working to repair a ride, the clutch holding the ride’s car opposite the repairmen failed sending the cars around the track. Hubby and two other workers fell 50 feet resulting in multiple fractures and life threatening injuries. Combine those injuries with 30 years of commercial truck driving, a near fatal lightning strike resulting in damage to his nerve sheaths and joints, along with degenerative disk disease, stenosis, scoliosis, and osteoarthritis ……

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The Government Waged a War on a Plant and LOST…

The plaintiffs, including an Iraq War veteran, a child with a seizure disorder and an ex-NFL player, claimed that the CSA’s classification of cannabis as a Schedule I substance is so “irrational” that it violates the U.S. Constitution.

via Lawsuit challenging Sessions and the DEA over marijuana’s Schedule I status dismissed by federal judge — The Cannabist

Here’s what’s legal — and what’s not — in Nevada as recreational weed sales begin — The Cannabist

Recreational marijuana becomes legal to buy Saturday in Nevada, but that doesn’t mean anything goes in the place where most people think anything goes.

via Here’s what’s legal — and what’s not — in Nevada as recreational weed sales begin — The Cannabist

6 Random Things You Probably Don’t Know About THC

 

 

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There are many fascinating things to know about tetrahydrocannabinol (THC), the primary psychoactive in cannabis. While much of the mainstream conversation revolves around whether or not THC is safe to consume, these conversations often miss highlighting some of the odd and unique characteristics of this plant molecule. For all of the cannabis enthusiasts out there, here are six random things you should know about THC.

1. THC is a fat

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Did you know that THC is a lipid? Lipids are fat molecules, and cannabis contains a lot of them. Since the primary active compounds in cannabis are fats, this means that they like to hang out in your fat after you consume them.

After inhaling cannabis, THC is absorbed by the lungs and then enters the bloodstream. From there, the psychoactive quickly makes its way to the fatty tissues it likes to call home, including the brain.

It is this quality that prevents THC from quickly exiting the body after consumption, which is why the average cannabis consumer can test positive for the herb for around 30 days after consumption.

For more information on how long THC stays in your system, check out the full article here.

2. A bunch of THC is released with fat burning

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Okay, this THC discovery is a bit surprising. There is some evidence that after an intense event which burns through a lot of fat, such as heavy exercise or rapid weight loss, levels of THC may be released back into the bloodstream.

There are some reports of ex-cannabis consumers testing positive for THC simply because they lost a lot of weight prior to testing.

On a more somber note, in 1997, a report highlighted anecdotal autopsy reports which showed abnormally large quantities of THC in the blood of drowning victims, who must have burned through significant amounts of fat before passing away.

Other research suggests that something as simple as 25 to 35 minutes of exercise in a cannabis consumer can elevate blood plasma levels of THC. Interestingly, one study shows that the larger a participant’s BMI, the more THC could be detected after exercise.

3. Most THC comes out in your poop

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So, THC gets itself into the bloodstream, then is stored in your fat cells where it is re-released into the bloodstream over time. But, where does THC go after that?

While it’s possible for a heavy cannabis consumer to test positive for cannabis metabolites in a urine test for up to 77 days after abstaining from the herb, most THC and THC metabolites are excreted in bowel movements.

In fact, it is estimated that more than 65 percent of THC consumed is excreted in the feces, whereas only 20 percent is excreted in urine.

Many people hoping to fake a drug test take advantage of this fat by consuming fruit pectin, a natural fruit fiber that theoretically forces more THC out through the stool rather than in urine or blood. However, there is no data on just how effective this method is in actuality.

4. Small amounts of THC can be found on you even if you don’t consume

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Interestingly, there may be a lot of THC floating around out there that you don’t even know about. Trace amounts of the cannabinoid are excreted in sweat, as well as in skin and hair oils.

When you shake hands with a cannabis consumer or touch things that they have touched, there’s a good chance that very tiny amounts of the herb can show up on you as well.

Some researchers in Germany think that this may be one of the reasons to argue against hair testing as a way to detect cannabis consumption. The standard theory suggests that cannabis ends up in the hair by transfer through the bloodstream.

However, these researchers have found some evidence that makes them question the standard beliefs about hair testing. In a tiny 2015 study of just two people, researchers tested hair growth during a time that each participant was given a controlled dose of a synthetic THC.

Hair grows at a fairly consistent rate in most people, meaning that each centimeter of hair provides a snapshot into your daily habits. After being treated with THC for 30 days, the researchers tested the participants’ hair. Surprisingly, they did not detect much of the stuff.

Even more surprising, when the researchers tested hair from a time the participants’ did not consume cannabis, compounds from the plant were present.

This lead the researchers to conclude that a good amount of the THC on the hair and the surface of the skin comes from external sources, like the environment and contact with the plant and those who love it.

5. Plants and fungus with similar compounds have been found

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Interestingly, other plants and some types of fungus have been found to contain compounds similar to THC. Black truffles, delicacies that can sell for $800 or more, have enzymes needed to create anandamide, the same THC-like compound that humans produce naturally.

Japanese and New Zealand liverwort, which are non-flowering plants, have also been found to contain compounds with similar actions to THC. These compounds are perrottetinene and perrottetinenic acid.

While the psychoactivity of these plants is questionable, the perrottetiene seems to activate the same cellular pathways that THC does, according to recent research.

Researchers have also genetically engineered yeasts that can produce the enzymes that create THC. Since the cannabis plant is illegal, this yeast might be a way for scientists to legally create natural THC that can be used for the large-scale production of medicines. However, this research is still in its early stage.

6. THC taps into our natural bliss pathway

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Have you ever wondered why consuming cannabis feels so good? Well, THC just-so-happens to tap into our body’s natural bliss control. As mentioned above, THC replaces a compound called anandamide (AEA) in the body. The word Ananda is Sanskrit for bliss, making anandamide our natural bliss molecule.

Both THC and anandamide bind to the same locations on cells. As it turns out, THC latches on to these cell sites for a little longer than anandamide, which is perhaps why the cannabinoid seems to have such a strong effect on the mind and body.

Anandamide was only discovered relatively recently, and there is still much to learn about the molecule’s role in the body.

However, a few interesting tidbits about the compound are known. Anandamide helps maintain mood, tells you when you’re hungry, is partly responsible for that feel-good high after exercise, and has many other key functions in the body.

A certain few who have won the genetic lottery have genes which hinder the breakdown of AEA. This may make these lucky folk naturally a little more chill and less anxious than the unfortunate majority without the needed gene mutations

UNM study suggests medical marijuana could decrease prescription opiate abuse

National Institute on Drug Abuse Updates Website, Now has “Marijuana as Medicine” Page

Colorado congressman says he’ll “fight the Attorney General” ~ The Cannabist

Rep. Mike Coffman suggested he’d use congress’ power to appropriate money for the administration’s budget.

DENVER — Rep. Mike Coffman is suggesting he might use the power of the purse to protect Colorado’s legal marijuana industry.

During a telephone town hall Wednesday evening the Republican congressman was asked about Attorney General Jeff Sessions’ threat to crack down on states like Colorado that have legalized recreational marijuana.

Coffman noted that he opposed the ballot measures that legalized both medical and recreational marijuana in the state. But he added that since voters approved them they are now Colorado law. He said the federal government should not interfere and he hopes Sessions doesn’t follow through on his warning.

If Sessions does take action Coffman said he’d “have to fight the Attorney General on this.” He suggested he’d do so through congress’ power to appropriate money for the administration’s budget.

Source: Colorado congressman says he’ll “fight the Attorney General” if need be on marijuana

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